Safety information

Last updated: 14 October 2026

Please read this before you start treatment, and keep it for reference. It covers the main safety information for the medications Senova’s physicians may prescribe. It does not list every possible side effect and does not replace advice from your physician or pharmacist.

About these medications

Senova’s medications are compounded by a US-licensed pharmacy and are not FDA-approved. Much of what is known about their safety comes from studies of approved medicines given in other forms, such as injections. The troche, tablet and spray forms prescribed through Senova have not been studied in the same way, so side effects may differ.

Your physician decides whether a medication is right for you based on your health questionnaire. Please answer it fully, including every medicine and supplement you take.

Bremelanotide — for low desire

How to use it safely

• Use it exactly as your physician prescribes.
• Dissolving tablet (troche): dissolve 1 troche under the tongue 30–60 minutes before sexual activity.
• Spray: 1 to 2 sprays in each nostril 30–60 minutes before sexual activity, as your physician directs.
• Do not use more than one dose in 24 hours, or more than 8 doses in a month.
• If you notice no improvement after 8 weeks, tell your physician.

Common side effects

• Nausea is the most common side effect and can be severe. In studies of the approved injectable form, about 4 in 10 women had nausea. Tell your care team if it bothers you.
• Flushing (about 1 in 5 women in those studies), headache and vomiting.
• Less often: a stuffy nose, cough, tiredness or dizziness.

Effects to know about

• Blood pressure and heart rate. After each dose, blood pressure can rise for a while and heart rate can slow. These usually return to normal within 12 hours. Contact your care team right away if you have a severe headache, blurred vision, a pounding feeling in your neck or ears, or a very slow heartbeat.
• Darker patches of skin or gums. These appear most often on the face, gums or breasts, are more likely in people with darker skin, and may not go away after you stop. Tell your care team if you notice them.

Do not use bremelanotide if you:

• have heart disease;
• have high blood pressure that is untreated or not under control;
• are allergic to bremelanotide;
• are pregnant. Use effective birth control while taking it, and stop and contact your care team if you become pregnant.

If you are breastfeeding, ask your physician before using it.

Other medicines

• Do not use it with naltrexone taken by mouth (used for alcohol or opioid dependence), because bremelanotide can make naltrexone less effective.
• It slows digestion, so other medicines taken by mouth may be absorbed more slowly. Tell your physician about every medicine you take, especially any where timing matters, such as some pain relievers or antibiotics.

Oxytocin — for lost connection

How to use it safely

• Use it exactly as your physician prescribes, and never use more than prescribed.
• Dissolving tablet (troche): dissolve 1 troche under the tongue 30–60 minutes before sexual activity.
• Spray: 1 to 2 sprays in each nostril 30–60 minutes before sexual activity, as your physician directs.
• Do not use more than one dose in 24 hours.

Common side effects

• Usually mild: nasal irritation or a runny nose (with the spray), headache, or mild nausea. In short-term research studies, side effects were no more common with oxytocin than with a placebo.
• Less often: dizziness, a fast or pounding heartbeat, or flushing.

Effects to know about

• Water and sodium balance. Oxytocin can make the body hold on to water, which lowers the level of sodium in the blood. This has mainly been seen with high doses given by injection. Avoid drinking unusually large amounts of fluid. Contact your care team if you have a severe headache, confusion, unusual drowsiness or muscle cramps, and call 911 if you have a seizure.
• Heart and blood pressure. Changes in heart rate or blood pressure are possible, especially in people with heart conditions.

Do not use oxytocin if you:

• are pregnant or could be pregnant, because it can cause contractions of the womb;
• are allergic to oxytocin.

Tell your physician before using it if you have high blood pressure, a heart rhythm problem, a seizure disorder or low sodium, or if you are breastfeeding.

Other medicines

Tell your physician if you regularly take anti-inflammatory pain relievers (such as ibuprofen), antidepressants, or medicines for your blood pressure or heart.

Bremelanotide and oxytocin together — for both

This option contains both medicines in one tablet, so everything above applies.

How to use it safely

• Dissolve ¼ to 1 tablet under the tongue 30–60 minutes before sexual activity, as your physician directs.
• If you’re worried about nausea, you can start with a smaller part of the tablet, such as ¼ or ½, as long as your prescription label allows it. Nausea with bremelanotide is more likely at higher doses.
• Do not use more than one tablet in 24 hours, or more than 8 tablets in a month.
• The tablet comes in two strengths. Your physician decides which one is right for you.

Storing your medication

• All Senova medications ship cold. Put them in the refrigerator (2–8 °C / 36–46 °F) as soon as they arrive, and keep them there unless the pharmacy label says otherwise. A tablet can stay at room temperature for a couple of hours, for example when you carry one with you.
• Keep all medications out of the reach of children.

When to contact your care team

Message your care team through the Messages tab in your patient portal if a side effect bothers you or doesn’t go away, if you start a new medicine or develop a new health condition, if you become pregnant or plan to, or if you have any question about your treatment.

For questions about orders, shipping or billing, write to hello@senovarx.com.

Reporting side effects

You can also report side effects to the FDA through MedWatch at www.fda.gov/medwatch or by calling 1-800-FDA-1088.

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